In vitro establishment of expanded-potential stem cells from mouse pre-implantation embryos or embryonic stem cells (2024)

Hamatani, T., Carter, M. G., Sharov, A. A. & Ko, M. S. Dynamics of global gene expression changes during mouse preimplantation development. Dev. Cell 6, 117–131 (2004).

Article CAS Google Scholar

Lyon, M. F. Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature 190, 372–373 (1961).

Article CAS Google Scholar

Gu, T. P. et al. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature 477, 606–610 (2011).

Article CAS Google Scholar

Guo, F. et al. Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote. Cell Stem Cell 15, 447–459 (2014).

Article CAS Google Scholar

Rougier, N. et al. Chromosome methylation patterns during mammalian preimplantation development. Genes Dev. 12, 2108–2113 (1998).

Article CAS Google Scholar

Bedzhov, I., Graham, S. J., Leung, C. Y. & Zernicka-Goetz, M. Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo. Philos. Trans. R. Soc. Lond. B Biol. Sci. 369, 20130538 (2014).

Saiz, N. & Plusa, B. Early cell fate decisions in the mouse embryo. Reproduction 145, R65–R80 (2013).

Article CAS Google Scholar

Evans, M. J. & Kaufman, M. H. Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154–156 (1981).

Article CAS Google Scholar

Kunath, T. et al. Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts. Development 132, 1649–1661 (2005).

Article CAS Google Scholar

Martin, G. R. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci. USA 78, 7634–7638 (1981).

Article CAS Google Scholar

Tanaka, S., Kunath, T., Hadjantonakis, A. K., Nagy, A. & Rossant, J. Promotion of trophoblast stem cell proliferation by FGF4. Science 282, 2072–2075 (1998).

Article CAS Google Scholar

Macfarlan, T. S. et al. Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature 487, 57–63 (2012).

Article CAS Google Scholar

Choi, Y. J. et al. Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells. Science 355, eaag1927 (2017).

Article Google Scholar

Morgani, S. M. et al. Totipotent embryonic stem cells arise in ground-state culture conditions. Cell Rep. 3, 1945–1957 (2013).

Article CAS Google Scholar

Yang, J. et al. Establishment of mouse expanded potential stem cells. Nature 550, 393–397 (2017).

Article CAS Google Scholar

Tarkowski, A. K. & Wroblewska, J. Development of blastomeres of mouse eggs isolated at the 4- and 8-cell stage. J. Embryol. Exp. Morphol. 18, 155–180 (1967).

CAS PubMed Google Scholar

Yamanaka, Y., Ralston, A., Stephenson, R. O. & Rossant, J. Cell and molecular regulation of the mouse blastocyst. Dev. Dyn. 235, 2301–2314 (2006).

Article CAS Google Scholar

Johnson, M. H. & Ziomek, C. A. The foundation of two distinct cell lineages within the mouse morula. Cell 24, 71–80 (1981).

Article CAS Google Scholar

Yagi, R. et al. Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development. Development 134, 3827–3836 (2007).

Article CAS Google Scholar

Nishioka, N. et al. The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev. Cell 16, 398–410 (2009).

Article CAS Google Scholar

Piccolo, S., Dupont, S. & Cordenonsi, M. The biology of YAP/TAZ: hippo signaling and beyond. Physiol. Rev. 94, 1287–1312 (2014).

Article CAS Google Scholar

Azzolin, L. et al. YAP/TAZ incorporation in the beta-catenin destruction complex orchestrates the Wnt response. Cell 158, 157–170 (2014).

Article CAS Google Scholar

Sonderegger, S., Pollheimer, J. & Knofler, M. Wnt signalling in implantation, decidualisation and placental differentiation--review. Placenta 31, 839–847 (2010).

Article CAS Google Scholar

Chan, S. W. et al. Hippo pathway-independent restriction of TAZ and YAP by angiomotin. J. Biol. Chem. 286, 7018–7026 (2011).

Article CAS Google Scholar

Wang, W., Huang, J. & Chen, J. Angiomotin-like proteins associate with and negatively regulate YAP1. J. Biol. Chem. 286, 4364–4370 (2011).

Article CAS Google Scholar

Zhao, B. et al. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev. 25, 51–63 (2011).

Article Google Scholar

Wang, W. et al. Tankyrase inhibitors target YAP by stabilizing angiomotin family proteins. Cell Rep. 13, 524–532 (2015).

Article Google Scholar

Lu, C. W. et al. Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos. Nat. Genet. 40, 921–926 (2008).

Article CAS Google Scholar

Maekawa, M. et al. Requirement of the MAP kinase signaling pathways for mouse preimplantation development. Development 132, 1773–1783 (2005).

Article CAS Google Scholar

Li, X. et al. Calcineurin-NFAT signaling critically regulates early lineage specification in mouse embryonic stem cells and embryos. Cell Stem Cell 8, 46–58 (2011).

Article CAS Google Scholar

Kapoor, A. et al. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell 158, 185–197 (2014).

Article CAS Google Scholar

Shao, D. D. et al. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell 158, 171–184 (2014).

Article CAS Google Scholar

Wilson, M. B., Schreiner, S. J., Choi, H. J., Kamens, J. & Smithgall, T. E. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene 21, 8075–8088 (2002).

Article CAS Google Scholar

Martello, G. et al. Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell 11, 491–504 (2012).

Article CAS Google Scholar

Ying, Q. L. et al. The ground state of embryonic stem cell self-renewal. Nature 453, 519–523 (2008).

Article CAS Google Scholar

Zimmerlin, L. et al. Tankyrase inhibition promotes a stable human naive pluripotent state with improved functionality. Development 143, 4368–4380 (2016).

Article CAS Google Scholar

Kim, H. et al. Modulation of beta-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat. Commun. 4, 2403 (2013).

Article Google Scholar

Ryan, D. J., Yang, J., Lan, G. & Liu, P. Derivation and maintenance of mouse expanded potential stem cells. Protoc. Exch. https://doi.org/10.1038/protex.2017.102 (2017).

Baker, C. L. & Pera, M. F. Capturing totipotent stem cells. Cell Stem Cell 22, 25–34 (2018).

Article CAS Google Scholar

Niakan, K. K., Schrode, N., Cho, L. T. & Hadjantonakis, A. K. Derivation of extraembryonic endoderm stem (XEN) cells from mouse embryos and embryonic stem cells. Nat. Protoc. 8, 1028–1041 (2013).

Article CAS Google Scholar

Matsunari, H. et al. Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs. Proc. Natl. Acad. Sci. USA 110, 4557–4562 (2013).

Article CAS Google Scholar

Yang, Y. et al. Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell 169, 243–257.e25 (2017).

Article CAS Google Scholar

Hemberger, M. et al. Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives. Dev. Biol. 257, 371–381 (2003).

Article CAS Google Scholar

Yang, J. et al. Signalling through retinoic acid receptors is required for reprogramming of both mouse embryonic fibroblast cells and epiblast stem cells to induced pluripotent stem cells. Stem Cells 33, 1390–1404 (2015).

Article CAS Google Scholar

Hung, S. S. et al. Repression of global protein synthesis by Eif1a-like genes that are expressed specifically in the two-cell embryos and the transient Zscan4-positive state of embryonic stem cells. DNA Res. 20, 391–402 (2013).

Article CAS Google Scholar

Sasaki, H., Ferguson-Smith, A. C., Shum, A. S., Barton, S. C. & Surani, M. A. Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos. Development 121, 4195–4202 (1995).

CAS PubMed Google Scholar

Thomas, K. R. & Capecchi, M. R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51, 503–512 (1987).

Article CAS Google Scholar

McMahon, A. P. & Bradley, A. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073–1085 (1990).

Article CAS Google Scholar