NFL expert picks, predictions for Week 10 straight up (2024)

Thursday, 8:20 p.m. ET, FOX/NFL Network

AFC South rivals meet with the division lead on the line, andthe Colts'second-ranked run defense will be a test for Tennessee.The Titans have lost the last two meetings at home, but they win a close on here.

Pick:Titans 24, Colts 22

Sunday, 1 p.m. ET,FOX

The Browns had a bye week to get healthy, and Baker Mayfield and Deshaun Watson can put on a show knowing both pass defenses are weak. The difference will be Houston's inability to stop the run. Cleveland gets back on the winning track, but the Texans can steal this game if Mayfield doesn't protect the football.

Pick:Browns 34, Texans 27

Sunday, 1 p.m. ET, FOX

The Packers are huge favorites at home, and lines like that are risky given how up-and-down Green Bay's defense has been.Jacksonville can slow the game down a little bit with James Robinson at running back, but they can't keep with the Packers'offense for four quarters.

Pick:Packers 33, Jaguars 19

Sunday, 1 p.m. ET, FOX

Alex Smith threw three interceptions in the loss to the Giants last week, but he also had two 100-yard receivers in Terry McLaurin and Cam Sims. Matthew Stafford threw two picks last week, too, and the veteran quarterbacks will playa typical wild game as a result.There is a potential upset here.

Pick:Washington 27, Lions 24

Sunday, 1 p.m. ET,FOX

The Eagles had a bye week to prepare for the rematch with the Giants,and Carson Wentz had 359 passing yards in the first meeting. New York kept the first meeting close and have improved in the running game, but Philadelphiaincreases its lead in a weak division with a season sweep.

Pick:Eagles 28, Giants 23

Sunday, 1 p.m. ET, FOX

Tom Brady bounced back to beat the Panthers after the first loss to the Saints in Week 1, and he will do it again here. Carolina's Christian McCaffrey suffered yet another injury, and that's going to make it that much more difficult to keep up. Antonio Brown scores his first TD of the season, too.

Pick:Buccaneers 27, Panthers 20

Sunday,4:05p.m. ET,CBS

DerekCarrhas averaged just 138 passing yards per game in the Raiders'last two victories, but they have been able to run the ball effectively.Denver's Drew Lock has established connections with rookie receivers Jerry Jeudy and KJ Hamler, and we're going to try an upset for the second straight week. If the Broncos can run the ball, then it will happen.

Pick:Broncos 29, Raiders 27

Sunday,4:05 p.m., CBS

Can TuaTagovailoalead a playoff run? It's starting to become a real question, and it will be amplified when the Dolphins win here. Miami's defense has allowed 17 points or less the last three weeks.That's the difference against rookie Justin Herbert.

Pick:Dolphins 27, Chargers 24

Sunday,4:05p.m. ET, CBS

The Bills upset the Seahawks in Week 9 and continue that momentum on the road against the Cardinals. The matchup between Josh Allen and Kyler Murray should be fun.It's a game where one turnover could be the difference, and Buffalo has thebetter turnover margin.Buffalo pulls out the victory in a thriller.

Pick:Bills 28, Cardinals 25

Sunday, 4:25 p.m. ET,FOX

The Seahawks'defense remains an issue, and the Rams had a bye week to scheme for a key NFC West showdown.Los Angeles has won three of the last four meetings,all of which have been decided by five points or less. This time, Russell Wilson leads the game-winning drive.

Pick:Seahawks 31, Rams 28

Sunday, 4:25 p.m. ET,FOX

The 49ers were riddled by injuries and COVID-19 issues, and this game likely won't resemble last year's classic shootout. Drew Brees, who hasn't thrown an interception in the Saints'last three games, pushes New Orleans to a sixth straight victory.

Pick:Saints 35, 49ers19

Sunday, 4:25 p.m. ET, CBS

A nasty AFC North rivalry is renewed, and the Bengals are playing better around Joe Burrow. Ben Roethlisberger returned from a knee injury to lead the Steelers past Dallas.Burrow has taken 14 sacks in three division games, and Pittsburghleads the league with four sacks per game. That's the difference.

Pick:Steelers 31, Bengals 20

Sunday, 8:20 p.m. ET, NBC

Lamar Jackson led a 37-20 blowout against the Patriots on Sunday Night Football last season, and the Ravens jumped out to a 17-0 lead in that game. New England does not have enough offense to keep up, even if Bill Belichick can throw in a few wrinkles that slow the Ravens down this time.

Pick:Ravens 28, Patriots 18

Monday, 8:15 p.m. ET, ESPN

The Vikings are starting to climb back into the fringe of the NFC playoff race after back-to-back division wins. The Bears are trying to break a three-game losing streak.Kirk Cousins is 0-3 as a starter with Minnesota against Chicago, but he breaks that streak in a close game with the help of Dalvin Cook.

Pick:Vikings 24, Bears 21